Menopause to become the next game-changer in global femtech solutions industry by 2025 Indraprastha Apollo Hospitals releases first “Comprehensive Textbook of COVID-19” It will modernise antivenom development by leveraging genomics, recombinant protein expression and synthetic antibody development technologiesIn the January 2020 issue of Nature Genetics, scientists from SciGenom Research Foundation (SGRF), India, AgriGenome Labs, India, MedGenome, India/USA, SciGenom, India, and Genentech, a member of the Roche group, along with a team of international collaborators from academia and industry report the sequencing and assembly of a high-quality genome of the highly venomous, medically important Indian cobra (Naja naja). Using a combination of cutting-edge genomic technologies, the authors have assembled the most contiguous genome of this iconic venomous snake.Venom is a complex mixture of proteins encoded by genes that have been co-opted by some snakes as they evolved some 100 million years ago. In the Indian cobra genome, the authors identified 19 key toxin genes primarily expressed in the venom glands.“Targeting these 19 specific toxins using synthetic human antibodies should lead to a safe and effective antivenom for treating Indian cobra bites” said Dr Sekar Seshagiri, President, SGRF, Former Staff Scientist at Genentech, and lead study author. Currently, antivenom is produced by immunising horses with extracted snake venom and is based on a process developed well over 100 years ago. This process is laborious and suffers from a lack of consistency leading to varying efficacy and serious side effects.“It is about time we modernise antivenom development by leveraging genomics, recombinant protein expression and synthetic antibody development technologies. The Indian cobra genome and the catalogue of target toxins are a blueprint needed to do this. For the first time, we now have a full list of venom-relevant toxin genes of the Indian cobra” said Dr R Manjunatha Kini, Professor, National University of Singapore (NUS), Singapore and an author on the study.“The Indian cobra is the first of the ‘big four’ deadly snakes to be sequenced. This is a major step towards understanding its venom components and it will effectively change the way antivenom is developed” said Dr George Thomas, Chief Operating Officer, AgriGenome Labs, India. He further added, “This study has provided a very high-quality reference genome that will make assessment of the Indian cobra genetic diversity possible and practical. It will be an important resource for conservation of this revered and feared Indian snake.”“Obtaining the genomes and the venom gland genes from the other three of the ‘big four’ and the deadly African snakes such as the black mamba, carpet viper and spitting cobras is the logical next step. It will provide a complete platform for developing a safe, universal antivenom for snakebite victims all over India, Africa and other neighbouring countries,” added Dr R Manjunatha Kini.Safe and effective antivenom is a major unmet social need in India and other parts of the world. The World Health Organisation (WHO) has classified snakebite as a neglected tropical disease (NTD). Institutions such as the Welcome Trust have announced funding for development of better antivenom. The Dept of Biotechnology, under the Ministry of Science and Technology, Govt of India, has also announced funding opportunities for antivenom development in India. These developments along with the insights gained from genome sequencing as reported in Nature Genetics, will help develop better antivenom that can end the snakebite crisis. Share MaxiVision Eye Hospitals launches “Mucormycosis Early Detection Centre” Heartfulness group of organisations launches ‘Healthcare by Heartfulness’ COVID care app By EH News Bureau on January 7, 2020 Read Article The missing informal workers in India’s vaccine story News WHO tri-regional policy dialogue seeks solutions to challenges facing international mobility of health professionals Scientists decode Indian cobra genome, identify 19 key toxin genes Phoenix Business Consulting invests in telehealth platform Healpha AgriGenome Labsblack mambacarpet viper and spitting cobrasGenentechIndian cobra genomeMedGenomeNaja najaNature Geneticsneglected tropical diseaseRoche groupSciGenomSciGenom Research FoundationThe Dept of BiotechnologyThe World Health OrganisationVenom Related Posts Add Comment Comments (0)
Union Bank,Kenneth D Gibbons, Chairman of Union Bankâ s Board of Directors, has announced the promotions that took place at the Bankâ s Annual Meeting held on May 16, 2012. David S Silverman, President of the Union Bank was promoted to Chief Executive Officer, the final step in a succession plan for leadership that began in 2010. Silverman was also promoted to Chief Executive Officer of Union Bankshares, Inc.Silverman began employment with the Bank in 1986 and progressed through numerous departments and positions to his current Bank position of President. Silverman previously held positions as Senior Vice President (1994), Senior Commercial Lender (1999) and Senior Loan Officer (2008). He became President of Union Bankshares, Inc. in April 2011 and had previously been a Vice President of Union Bankshares since 2008.Silverman is an active member of the community, currently serving as Treasurer of Copley Professional Services Group d/b/a Community Health Services of Lamoille Valley, a non-profit primary health care organization. Mr. Silverman is also currently serving on the Board of the Lamoille Economic Development Corporation (LEDC) and on the Executive Committee of Vermont Bankerâ s Association. He has also held the positions of Treasurer and Executive Committee Member of the Stowe Area Association, Member of the Morristown/Morrisville Development Review Board, Commissioner of the Town of Hardwick Electric Department, and has served on the Board of Directors of Lamoille County Mental Health. He also volunteered as an Umpire for Little League and Babe Ruth Baseball in Lamoille County.Stephen H. Kendall was promoted to Senior Vice President, Retail Lending and will become a member of the senior management team. Kendall currently serves as the Senior Retail Officer. He has been with Union Bank since January 2002 and in the banking industry for more than two decades. A native Vermonter, Kendall is on the Board of the Lyric Theatre Company and resides in Shelburne.In addition, five employees were promoted to the officer level. Barbara J. Churchill, Loan Servicing Manager; Jennifer Degree, Electronic Banking Manager; Jessica Eastman, Retail Loan Underwriter; and Lesley R. Russ, Loan Review and Internal Auditor were promoted to Assistant Treasurer. Paul Grogan was promoted to Facilities Officer.Judy R. Smith, Branch Manager for the Bankâ s St. Albans office and Claire Hindes, Branch Manager for the Bankâ s main branch in Morrisville were promoted to Vice President.Union Bank, a wholly-owned subsidiary of Union Bankshares, Inc. (UNB, traded on the NASDAQ Exchange), has been helping people buy homes and local businesses create jobs in area communities since 1891. Headquartered in Morrisville, VT, Union Bank is a full service bank offering deposit, loan, trust and commercial banking services throughout northern Vermont and northwestern New Hampshire. Union Bank has earned an outstanding reputation for residential lending programs and is an SBA Preferred Lender.Proud to be one of the few community banks serving Vermont and New Hampshire, Union Bank maintains a strong commitment to traditional values. In particular, Union Bank is dedicated to providing genuine customer service and community support, donating tens of thousands of dollars to local nonprofits annually. These valuesâ combined with financial expertise, quality products and the latest technologyâ make Union Bank the premier choice for your banking services, both personal and commercial. Union Bank currently maintains 18 banking offices and 34 ATMs. Member FDIC. Equal Housing Lender.Caption: David Silverman, President and Chief Executive Officer, Union Bank
Dec 28, 2010Global swine flu surveillance seen as seriously inadequateAn article published yesterday in Scientific American explores what experts see as the vastly inadequate global efforts to monitor influenza viruses in swine, in the wake of a pandemic caused by a swine flu virus that jumped to humans. Reporter Helen Branswell writes that most pork-producing countries don’t test their swine herds for flu at all. In the United States, pork producers generally test their animals, but they don’t usually share the results with public health officials, since they know that any news about swine flu scares people away from eating pork. The Centers for Disease Control and Prevention (CDC) recently worked with the US Department of Agriculture to launch a program to share animal testing results with the public health sector, Branswell reports. But the program has limitations, in that swine flu surveillance data are stripped of identifying information, so health officials know what state a sample came from but not what county or farm. And when a human case of swine flu occurs, the herd suspected as the source can be tested only with the owner’s permission. Flu experts are planning a February meeting in Italy to try to find ways to overcome the barriers to better surveillance, the article says.Dec 27 Scientific American articleSalmonella probe points to Illinois farm as source of sproutsPreliminary findings in an investigation of the 15-state Salmonella outbreak linked to Jimmy John’s restaurants point to Tiny Greens Organic Farm of Urbana, Ill., as the source of contaminated sprouts, the Food and Drug Administration (FDA) announced yesterday. The FDA said consumers should not eat alfalfa sprouts and “Spicy Sprouts” (which contain alfalfa, radish, and clover sprouts) from Tiny Greens. The products were distributed in 4- and 5-ounce containers to farmers’ markets, restaurants, and grocery stores in Illinois, Indiana, Iowa, Missouri, and possibly other Midwestern states. In a Dec 23 report on the outbreak investigation, the CDC said 89 patients with a matching strain of Salmonella serotype I 4,,12:i:-were reported by 15 states and Washington, DC, between Nov 1 and Dec 21, including 50 cases in Illinois. Among patients with available information, 23% reported being hospitalized, but there were no deaths, the CDC said. In other developments, J&D Produce of Edinburg, Tex., yesterday announced the “precautionary” recall of curly parsley and cilantro after samples tested positive in Quebec and Detroit. The recall applies only to products packed on Nov 30 and Dec 6, and no illnesses have been reported, the company said in a statement. The products were packed in red, white, and blue waxed cartons and sold under the Little Bear brand at retail outlets and wholesale terminal markets. A CNN report said the recall involved close to 7,000 cases of the products, which were distributed in several US states as well as Quebec and Ontario.Dec 27 FDA press releaseDec 23 CDC report on outbreak investigationDec 28 CNN story on Texas firm’s recallHaiti’s cholera cases approach 130,000Cholera continues to engulf Haiti, with nearly 130,000 cases and 2,707 deaths reported so far, the Jamaica Observer reported today. Even with ongoing international efforts to contain the epidemic, an estimated 40 people are dying each day, the Haitian health ministry said. Worst hit is the Artibonite province in central Haiti, but infection has spread all over the country. Adding to the strife currently are attacks on voodoo priests in the southwestern part of the country by mobs claiming that they are responsible for the outbreak; more than 40 priests have been killed.Dec 28 Jamaica Observer articleFlu vaccination policy in UK debatedThe UK Department of Health is coming under fire for not offering free flu shots to healthy children under 5 years of age this flu season. The shots are being recommended only for high-risk groups this season, including pregnant women and the elderly but not young children. The current vaccination policy follows the recommendations of the independent Joint Committee on Vaccination and Immunisation. During last season’s H1N1 pandemic, all age-groups were urged to obtain vaccination. Some critics claim that preschoolers were left off the shot roster this season to save money, but the health department claims the decision was made because of age and risk considerations. No vaccination campaign has been directed at the general public this year; only high-risk people have been contacted to get the vaccine. Public schools in the United Kingdom reopen next week after the holiday recess, and concern is mounting that flu, which is currently seeing a surge there, will reach epidemic proportions.Dec 28 BBC articleDec 28 The Guardian articleDec 28 The Telegraph articleEgyptian girl dies of H5N1; Japan, Korea cite bird deaths A Dec 25 death in Egypt from H5N1 avian flu brings the number of deaths from the disease there to 11 this year and 38 since the outbreak began in 2006. The latest victim was an 11-year-old girl in the Luxor governorate who had been reported as hospitalized last week. Meanwhile, reports of H5N1 deaths in birds have come in from Japan and South Korea. Three cranes were found dead in the Izumi Plains of Kogoshima prefecture Dec 21 and subsequently tested positive for H5N1, according to a Kyodo News International article, bringing the recent total to five. In South Korea, the farm ministry reported today that 20 spectacled teal ducks had been found dead south of Seoul, apparently from H5N1. This is the third such report from the area this month.Dec 25 Kuwait News article on Egyptian deathDec 27 Kyodo News article on Japanese cranesDec 28 Yonhap News article on South Korea
MEMPHIS, Tenn. – David Rognlien, founder and chairman of the board of CADNA Automotive Inc., has reached an agreement with Devin Hart, the company’s president and CEO, for Hart to acquire a significant ownership stake in the company. Specific terms of the agreement were not disclosed. CADNA Automotive is an aftermarket supplier and licensee of well known premium brands: Prestone, Autolite, FRAM and proprietary brand ARMOR MARK.AdvertisementClick Here to Read MoreAdvertisement “In a short amount of time, Devin has done an outstanding job of setting into motion a strategic vision that challenges the company to proceed in new directions,” said Rognlien. “I’m confident that under his leadership he will help us execute our long-term growth strategy and improve our market share both domestically and worldwide.” A 15-year veteran of the automotive aftermarket, Hart became president and CEO of CADNA Automotive in April 2009. Previously, he was vice president of sales and marketing for Disa Automotive Inc. and a former director and national sales manager for Federal-Mogul. “It is a privilege to become a CADNA shareholder and work closely on the board with David, to guide the company to its full potential,” said Hart. “I am excited to lead the company during these challenging, yet opportunistic times. The recent change in ownership status helps solidify our partnership in this endeavor.”,Lubrication Specialties Inc. (LSI), manufacturer of Hot Shot’s Secret brand of performance additives and oils, recently announced the expansion of senior leadership. Steve deMoulpied joins LSI as the company’s chief operating officer (COO). AdvertisementClick Here to Read MoreAdvertisement DeMoulpied has a Bachelor of Science degree in Engineering Management from the United States Air Force Academy and a Master of Business Administration degree from the University of Dayton in Marketing and International Business. He served six years with the USAF overseeing the development of technology used on fighter aircraft and the E-3 Surveillance aircraft, finishing his career honorably as Captain. LSI President Brett Tennar says, “Steve’s success in developing operational strategies that improves the bottom line, builds teamwork, reduces waste and ensures quality product development and distribution checks many of the boxes of what we were looking for in a COO. This, coupled with his career in the Air Force working with highly technical systems and his in-depth understanding of Lean Six Sigma and Business Process Management sealed our offer. As our tagline states, our products are Powered by Science. This data driven approach is one reason why our company has grown exponentially as we employ the most advanced technology to product development. I am confident that Steve is the right person to drive operational strategy for our diverse and growing brands.” Advertisement With more than 20 years of experience across multiple industries and functional areas, deMoulpied has particular expertise in organizations with complex technical products. Combined, his prior positions have required a spectrum of skills in corporate strategy, operations improvement, product quality, and revenue cycle management. He has an impressive history of utilizing data driven problem solving (Lean Six Sigma) and project management (PMP and CSM) to achieve strategic goals surrounding customer satisfaction, operational efficiency and improved profit. DeMoulpied comes to LSI from the Private Client Services practice of Ernst & Young where he managed strategy & operations improvement engagements for privately held client businesses. Some of his prior roles include VP of strategic development, director of strategic initiatives, and Lean Six Sigma Master Black Belt at OptumHealth, UnitedHealth Group’s health services business, as well as Lean Six Sigma Black Belt at General Electric, where he applied operations improvement principles to customer service, supply chain and product development. A successful entrepreneur, deMoulpied is also the founder of PrestoFresh, a Cleveland-based e-commerce food/grocery business.
* The SA Teens organisation hosted an entrepreneur breakfast at The River Club in Observatory on Saturday May 14. The aim was to speak to the youth who are part of the programme about their futures and how to become an entrepreneur. Pictured is guest speaker Delia Cupido, from Athlone.
Aces head coach Alex Compton expects his team to give a good fight – even score an upset – against Painters at the Ynares Center in Antipolo City.“We don’t have a chance but we’re still going to compete,” Compton said. “We just want a win to close out our campaign. The season’s over at the sound of that last buzzer on Wednesday.”Aces’ hopes of reaching the quarterfinals were doomed when Blackwater Elite beat Alaska’s fellow eliminated squad GlobalPort Batang Pier 118-107 on Sunday night.“I was really praying (for a GlobalPort win last Sunday). I was at the church. Unfortunately [my prayer] was not answered,” Compton said. “But Blackwater really earned that victory. They did a good job.”Alaska had a poor start in the conference. It lost its first six matches before racking up three straight wins. But Aces encountered a huge roadblock in its match against Meralco Bolts.“I was mad after the Meralco game. In a game where we needed our best effort, we brought less than our best,” Compton said. “I think the bottom line was we didn’t squeeze out wins and a few games that we really needed that were crucial.”“It was a crazy conference. It’s been a crazy year. We’re done for the whole season, and there’s going to be a whole lot of time for looking back and analyzing and reflecting, and we got to make us better.”ILONGGA UST VOLLEY CAPTAINShannen Palec was named the new team captain of the University of Santo Tomas Golden Tigresses as the team prepares for the UAAP Season 80 volleyball tournament.A native of the component city of Passi in Iloilo province, Palec will do co-captain chores with libero Rica Jane Rivera, replacing the high-leaping spiker Cherry Rondina, said Golden Tigresses head coach Emilio Reyes.“Si Shannen na iyong pinaka-ate ng lahat. This time, bago siya um-exit, ma-exercise niya naman iyong pagiging leader na in authority talaga siya,” Reyes told Varsitarian.net.Palec, who will be playing in her final year in the upcoming season, said she does not mind her position in the squad but is willing to do everything to help her team reach its goals in UAAP Season 80.“Expected na ako na mag-lead sa team kasi ako na iyong pinaka-senior. Para sa akin may pressure pero iniisip ko lang kung paano ko sila ili-lead at paano madadala iyong mga games,” said Palec, who also played for Cocolife in Philippine Superliga.In preparation for upcoming matches, Golden Tigresses is set to suit up in the Philippine Superliga Grand Prix. Its sponsor is yet to be announced.Golden Tigresses is hoping to improve on its third-place finish in the last UAAP season, where it reached the Final Four stage for the first time in years but lost to the eventual champion De La Salle University Lady Spikers./PN[/av_textblock][/av_one_full] [av_one_full first min_height=” vertical_alignment=” space=” custom_margin=” margin=’0px’ padding=’0px’ border=” border_color=” radius=’0px’ background_color=” src=” background_position=’top left’ background_repeat=’no-repeat’ animation=”][av_heading heading=’ BUZZER BEATER Spoiler’s role’ tag=’h3′ style=’blockquote modern-quote’ size=’30’ subheading_active=’subheading_below’ subheading_size=’15’ padding=’10’ color=” custom_font=”]BY ADRIAN STEWART CO[/av_heading][av_textblock size=” font_color=” color=”]Wednesday. September 20, 2017[/av_textblock][av_textblock size=” font_color=” color=”]AFTER its unceremonious exit from the playoff contention in the PBA Governors’ Cup, Alaska Aces hopes to play the spoiler’s role when it battles Rain or Shine Elasto Painters tonight to close out its season campaign.
Kurt Suzuki C Here is the Nationals lineup! Adam Eaton RF Victor Robles CF Brian Dozier 2B Anthony Rendon 3B Juan Soto LF With a 55-46 record, the Nationals send staff ace Max Scherzer to the mound for his twentieth start of the 2019 season. The Rockies send right-handed Jeff Hoffman. The Rockies come into the game with a 47-55 record. Matt Adams 1B Trea Turner SS The Washington Nationals face the Colorado Rockies at Nationals Park for their 102nd game of the regular season. Max Scherzer SP Please follow and like us:
Now running out of substitutes however, the Tigers offensive machine sputtered to a halt and they could not push any more runs across the plate, ending the game in a tough 9-6 loss.Game 2 started with a team turned upside down to get some of the injured the deserved rest the craved for and coach Young started with 4 new faces in the side. It seemed to work well as the Tigers again came out steaming, grabbing a 4-1 early lead after the top of the 2nd inning, mainly through 2 monster ‘no doubt’ home runs from Toom Suratit and Pipo Engchuen.This seemed to wake up the power house MSport team as they suddenly switched on their own offensive arsenal, hitting some timely bombs out of the park as the Tigers started to make errors and the visiting defense began to stutter.At 15-4 in favour of the home team it was close to a mercy rule score and it was time once again for coach Young to make more changes, bringing back all his principle players (injured or not) into the lineup. The move worked and the Tigers scored 4 runs in the 6th, closing the gap to a more respectable 15-8.At the top of the 7th it was all or nothing for the Tigers and again they seemed to pull that extra effort out of their hats, scoring 2 quick runs to reduce the deficit to just 5. The team manager called for one more big effort and with 3 more hits loading up the bases for powerful hitter Toom Suratit it looked like the impossible might just become possible, but a good defensive stop up the middle ended the Pattaya team’s hopes of a dramatic come-back, effectively ending the game with a final score of 15-10 to MSport.The team will have a chance to recover from all their niggling injuries as they have a bye next week in the BISL League.If you would like to get involved in some fun baseball or softball in Pattaya, contact Dirk at [email protected] Alternatively you can drop by team sponsor Fraser’s Sports Bar and Restaurant and ask Stewart on how to find the Tigers. The bar can be found on Thappraya Road in Jomtien. After chalking up two wins on the opening weekend of the season, the Pattaya based Thai Tigers team was full of confidence going into week 2 of the prestigious BISL League in Bangkok. However, they did not expect an easy time as they were taking on last year’s One Pitch tournament co-champions MSport. Before the game the Tigers received a setback as 4 of their starters were found to be carrying injuries, though this did not dampen the team’s self-belief and they began well by bringing the fight to the free slugging MSport, grabbing an early 2-1 lead after 2 innings.The experience of the MSport players gradually kicked in however and they fast found the Tigers’ weak spots with well-placed hits through the depleted defense, jumping over the visitors 8-3 after 6 innings. As the top of the 7th, MSport scored one more run to make it 9-3 which prompted coach Young of the Tigers to ring the changes in his lineup, resulting in 5 base hits in a row and closing the gap to 9-6 and getting the tying run at the plate with no outs and runners on 1st and 2nd base.
The long wait for the Hilton Pattaya volleyball team is finally over after they defeated the 5-time defending champions Asia Hotel in the Thailand Hotels Association (THA) male volleyball competition held recently in the gymnasium of the Pattaya Muang 8 School. With over two months of hard practice the team got its just reward and was helped in no small measure by the fantastic support of their Blue Energy cheerleading team. Well done Hilton Pattaya!Harald Feurstein, General Manager of Hilton Pattaya (standing 3rd left) poses for a photo with the victorious Hilton Pattaya male volleyball team.
Wide receiver Tyler Boyd runs the 40-yard dash for NFL scouts at a Pro Day college football workout at Pittsburgh, Wednesday, March 16, 2016 in Pittsburgh. (AP Photo/Keith Srakocic)PITTSBURGH (AP) _ Tyler Boyd shook out his legs, put his hands on the goal line and tried not think about the most important 4.5ish seconds of his football life.The former Pittsburgh wide receiver took off in a flash, his white compression shirt, gray shorts and green-and-orange cleats a blur as two dozen NFL scouts looked on, thumbs hovering over stopwatches. Boyd powered his way through the end of his 40-yard dash, the scouts hitting the “stop” button in near unison.You’d think Boyd’s school-record 254 catches during his three years with the Panthers would have been enough. Or his 22 career touchdowns. Or the way he glided through opposing defenses like a Ferrari amid a pack of minivans. Yet there Boyd was on Wednesday, his draft prospects hinging in part on getting the scouts and the teams they work for to hit “erase” on his forgettable 40 time at the NFL combine last month.Admittedly a little too amped up in Indianapolis, Boyd trudged to a 4.58, a glacial pace by NFL wide receiver standards. It’s the main reason Boyd _ projected as high as a second-round selection _ joined several of his lesser heralded former college teammates during Pitt’s Pro Day.Boyd seemed at ease with his performance on familiar turf at the UMPC Sports Complex, saying he was told he finished in the 4.46-4.47 range, the kind of speed he hopes will allay any fears about his ability to run away from defenders.“I knew I had 4.4 in me,” Boyd said. “I didn’t like my 40 at the combine, I knew I could improve.”Which is why Boyd didn’t bother to join the rest of the former Panthers _ including defensive linemen Khaynin Moseley-Smith and Darryl Render and defensive back Lafayette Pitts _ for the bench press, vertical leap, shuttle runs or most of the other drills. The 40 is all that mattered.“My main focus was just showing them my tools, especially in the 40 area,” Boyd said. “In the field I knew my craft was pretty much legit, it was sharp.”It certainly looked it while dazzling with his footwork during a brief session running routes before heading outside to field a few punts, all of which came after the 40-time that he hopes solidified his spot in the pecking order when the 2016 draft descends on Chicago from April 28-30. Boyd looked like a world-class sprinter as he prepped himself for the most important part of a very public job interview.“The big thing is to just go up to the line and just relax, be yourself,” Boyd said. “Don’t be anxious with all the anxiety built up in you because you’re nervous to run.”Boyd certainly looked comfortable in front of a large crowd that included former Panther and current Los Angeles Rams defensive lineman Aaron Donald and Pitt running back James Conner, who is undergoing cancer treatment. In a way, Boyd’s decision to run may have helped out Moseley-Smith, Render and others. Render watched Boyd at the combine and was a little surprised Boyd would put himself out there again at Pro Day. After spending three years watching Boyd do his thing, Render figured the last thing Boyd needed to do is prove how fast he is.“That game speed is going to be different,” Render said. “You know he’s going to do what he’s got to do on the field.”___AP college football website: www.collegefootball.ap.org